FLZ

We have studied the mechanism of antitumor activity of the two substances ( T α 1 、 FLZ), their common feature is the ability to reduce the level of intracellular oxidative stress.

研究两种在肿瘤细胞内表现出抗肿瘤活性的物质（Tα1、FLZ）的作用机理，其共同的特点是能够降低细胞内的氧化压力水平。

Chapter I: FLZ attenuats neuroinflammation and protects dopaminergic neurons through inhibiting Src tyrosine kinase.

第一章：FLZ通过抑制Src酪氨酸激酶减弱神经炎症并保护多巴胺能神经元。

FLZ can effectively inhibit the activity of tumor cells, but has little toxicity to normal liver cells, which may be associated with lower background level of ROS in normal cells.

FLZ能够有效地抑制肿瘤细胞的活性，但对正常肝细胞的毒性很小，这可能与正常细胞内低本底ROS水平有关。

Furthermore, FLZ could enhance BDNF signaling in the brains of AD model.

此外，FLZ可增强AD模型动物脑内BDNF信号。

Protection by New Compound FLZ and Ginkgo Biloba Extract ( EGb761) Against the Oxidization of Human Low Density Lipoprotein and Its Cytotoxicity to Macrophages and Vascular Endothelial Cells

新化合物FLZ和银杏叶提取物（EGb761）对人低密度脂蛋白过氧化及其损伤巨噬细胞及血管内皮细胞的保护作用

The squamosamide derivative FLZ has been shown to inhibit over-activated microglia and protect dopaminergic neurons in previous studies, but the mechanism remains unclear.

前期研究证实番荔枝酰胺衍生物FLZ可抑制过度活化的小胶质细胞，具有很强的神经保护作用，但具体作用机制仍然不十分清楚。

Preliminary mechanistic studies suggested that FLZ played neuroprotective effects by protecting the mitochondria and inhibiting neuronal apoptosis.

初步机制研究认为，FLZ可能通过保护线粒体和抑制神经元凋亡发挥神经保护作用。