aaid

The incidence of the 1555 A → G mutation in AAID and matrilineal non syndromic deafness pedigrees is fairly high.

1555A→G突变在西南地区AAID及非综合征性耳聋家系均有较高发生率。

Conclusion The inheritance mode of AAID is mitochondrial inheritance. Aminoglycoside antibiotic therapy should be avoided in those persons with a family history of AAID, especially their maternal relatives.

结论AAID属线粒体遗传，对具有AAID家族史的个体（尤其是母系亲属），应当避免使用氨基甙类抗生素。

Objective: The experiment was designed to research the relationship between mitochondrial DNA ( mtDNA) mutation and aminoglycoside antibiotic induced deafness ( AAID) and establish a gene diagnostic method.

目的：研究线粒体DNA突变与氨基糖甙类抗生素致聋（AAID）的关系，建立相应的基因诊断方法。