abortifacient

Model drug mifepristone was an effective abortifacient.

模型药米非司酮，是一种临床常用的抗早孕药物。

Aim: To study the effect of structural modification on the abortifacient activity of trichosanthin.

目的：研究结构改造对天花粉蛋白（TCS）引产活性的影响。

Trophoblast cells isolated from Human Villi of early pregnancy and Study on Mechanism of abortifacient effect by Verbena officinalis

人早孕绒毛滋养层细胞的分离纯化及马鞭草抗早孕机理的初步研究

Abortifacient effects of mifepristone combined with water bag and rivanol were observed in 187 cases.

目的:观察187例口服米非司酮联合水囊引产及联合利凡诺引产的临床疗效.

Methods: Glutamine residue in 219 of trichosanthin was mutated into cysteine residue ( Q219C) by site-directed mutagenesis. The mutein was then modified by polyethylene glycol ( PEG). Ribosome-inactivating activity and abortifacient activity of the modified products were determined.

方法：利用定点突变将TCS第219位的天冬酰胺残基改变为半胱氨酸残基（Q219C）以供定点聚乙二醇（PEG）修饰，测定修饰产物的致核糖体失活活性及小鼠中期引产活性。

There was no significant change in abortifacient activity by 5 000 PEG modification, whereas the activity was significantly enhanced when TCS was modified by 20 000 PEG.

相对分子质量为5000的PEG修饰对引产活性无明显影响，而相对分子质量为20000的PEG修饰却明显增强引产活性；

Pinellin can be used as an abortifacient protein for terminating early pregnancy of mice.

半夏蛋白曾作为抗早孕蛋白，用于终止小鼠的早期妊娠。

To study the mechanism of abortifacient effect of extract of Verbena officinalis ( VO), trophoblast cells from human placenta of 6 ￣ 8 weeks early pregnancy was isolated with Percoll method and cultured in vitro.

正常妊娠6～8周人绒毛滋养层细胞以Percol分离、纯化及体外培养为实验手段，观察马鞭草提取液对滋养层细胞功能的影响，进一步探讨了马鞭草抗早孕的细胞学作用机理。

Effect of structural modification of trichosanthin on its abortifacient activity

天花粉蛋白结构改造对引产活性的影响