acys

Applying Lactacystin, a selective proteasome inhibitor, to set up the rat model of Parkinson's disease with Lewy body

应用蛋白酶体抑制剂Lactacystin建立有Lewy体的帕金森病大鼠模型

PD rats that expressed Lewy body and presented lateral rotation were made by injecting 8 μ g lactacystin into one side of substantia nigra compact part of rat with stereotaxic technique.

在大鼠单侧黑质致密部（SNc）立体定向注射蛋白酶体抑制剂lactacystin8μg，建立表达Lewy小体并向偏侧旋转的PD大鼠。

Conclusion: There is synergistic toxic effect between lactacystin and paraquat and the chronic exposure to paraquat can increase the risk for PD of rats with lightly impaired proteasome.

结论：lactacystin与PQ之间存在协同作用，长期小剂量PQ的暴露能显著增加蛋白酶体功能轻微损害的大鼠患PD的风险。

Synergistic Toxic Effect of Paraquat and Lactacystin on Substantia Nigra

百草枯与lactacystin对黑质细胞协同毒性作用

Preliminary Studies on the 43-kD Protein in Phycobilisomes of Cyanobacterium Anacystis nidulans R-2

蓝细菌Anacystis nidulans R-2藻胆体中43kD蛋白细胞定位的初步研究

A new signal peptidase recognition site has been found in the linker-encoded amino acid sequence.

由DNA顺序推知，linker区编码的氨基酸顺序SerGInAlaCys可能是新的信号肽酶识别位点；

Conclusion The rat model of Parkinson's disease with Lewy body is set up by using Lactacystin which can block the α-synuclein degradation.

结论利用蛋白酶体抑制剂Lactacystin阻碍α-synuclein的降解可以建立有Lewy体的PD大鼠模型。

Aim : To study the effect of lactacystin on dopamine ltransporter ( DAT ) and vesicular monoamine transporter ( VMAT 2 ) protein expressions in rats striatum.

目的: 探讨蛋白酶体抑制剂lactacystin对大鼠纹状体多巴胺转运体 ( DAT ) 和囊泡单胺转运体2 ( VMAT2 ) 蛋白表达的影响.

Effects of Lactacystin on the Expressions of Gene and Protein of Tyrosine Hydroxylase

Lactacystin对酪氨酸羟化酶基因和蛋白表达的影响

Transfer RNA genes range in length from 63 to 76 nt, their planar structure present characteristic clover leaf, except for tRNA-Cys and tRNA-Ser ( AGY) because of lacking the D arm.

tRNA基因核苷酸长度为63～76nt，除了tRNACys和tRNASer（AGY）缺少D臂，其余的二级结构均呈典型的三叶草状。