bcpt

Effect of BCPT on AVP content of hypothalamus and pituitary and AVP mRNA of hypothalamus in chronic stress rats

BCPT对慢性应激抑郁大鼠下丘脑、垂体AVP含量及下丘脑AVP mRNA表达的影响

BCPT could increase body weight, sweet water wastage and the crossing scores and rearing scores of the depression model rats.

与模型组大鼠相比，BCPT组大鼠体重增长略有提高，糖水消耗量明显增加，水平活动和垂直活动均明显增加。

Results BCPT could reverse the blepharoptosis and the akinesia induced by reserpine and increase the number of head-twitches induced by 5-HTP in mice.

结果BCPT可拮抗利血平诱导的小鼠上眼睑下垂及运动不能，并增加5-HTP诱导的小鼠甩头次数。

Conclusion BCPT produces antidepressant-like effect in drug-induced animal models in mice.

结论BCPT对药物诱导的抑郁小鼠具有一定的抗抑郁作用.

CONCLUSION: BCPT can improve the anhedonia condition of rats with depression, which may related with the regulation of immunological function and cell factor levels;

结论：拟青霉代谢物提取物可改善抑郁大鼠快感缺乏，该作用的发挥可能与调节免疫功能和细胞因子水平有关；

Once administration of 100 mg/ kg BCPT had certain inhibition effect on MAO-A in brain tissues of mice, while 4 hours after administration with BCPT, the inhibition ratio of MAO-A was 66.7%.

拟青霉代谢物提取物100mg/kg1次性给药对小鼠脑组织单胺氧化酶A具有一定的选择性抑制作用，拟青霉代谢物提取物给药后4h，对小鼠脑组织单胺氧化酶A的抑制率达到66.7%。