busulfan

Pharmacokinetics of Oral Busulfan in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

大剂量口服白消安在异基因造血干细胞移植预处理患者体内药动学研究

Mice were treated with Busulfan for a month to remove the spermatogonial stem cells and data processed and analyzed as the same.

对小鼠腹腔注射Busulfan，去除精原干细胞，一个月后取材，用相同方法检测Sertoli细胞的核孔数量。

Results Limb defect was the main type of defect occurring on gestational day 12 with 25mg/ kg of Busulfan.

结果在大鼠受孕第12天（GD12），一次经口给予白消安25mg/kg时，胎仔畸形类型主要为肢体畸形。

Plasma Busulfan Concentration Monitoring and Clinical Benefit in Hematopoietic Stem Cell Transplantation

造血干细胞移植中白消安血药浓度监测及其临床意义

After treated with high dosage of busulfan, the seminiferous cord in testes reduced obviously and arranged in disorder.

高剂量白消安处理导致睾丸曲细精管数明显减少，排列紊乱。

Induction of Azoospermia Model in Mice by Busulfan

白消安诱导小鼠无精子症模型

Results In the group of benzene and busulfan used for 5 weeks, the incidence of acute aplastic anemia was 100% as well as the mortality.

结果苯白5周组急性再生障碍性贫血的患病率为100%，死亡率为100%，平均存活时间为（43.5±6.9）d。

Treated with 40mg/ kg weight busulfan, the germ cells in mouse testis were destructed. After 4-6 week, it was used as recipient.

40mg/kg体重的白消安处理，对受体小鼠的生精能力破坏最大，处理后4～6周可作为无内源性生殖干细胞的受体，用于精原细胞的异种移植。

These results showed that the increasing dosage of busulfan was positively correlated with both the death rate of embryos and the structural abnormalities of testes and ovaries.

以上结果表明：白消安剂量的增加与鸡胚死亡率及睾丸和卵巢结构异常呈正相关。