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Induction and inhibition of cytochrome P 450 ( CYP 450 ) catalytic activity has been concluded to be pharmacokinetic drug-drug interaction.

细胞色素P450酶 ( CYP450 ) 活性的诱导或抑制,是引起临床药物代谢性相互作用的主要作用机制.

Research on genetic polymorphism of CYP 450 s is significant to drug design, screening, evaluation and optimization.

研究CYP450对新药设计 、 筛选 、 评价及优化有重要意义.

Conclusion: Atorvastatin, which is metabolited through the cytochrome P 450 ( CYP ) 3 A 4 Pathway, does not inhibits the antiplatelet activity of clopidogrel.

结论: 经细胞色素P4503A4 ( CYP3A4 ) 途径代谢的阿托伐他汀不抑制氯吡格雷的抗血小板活性.

Methods: The hydrocortisone probe was used to determine the CYP 3 A activity.

方法用氢化可的松探针测定健康儿童个体内CYP3A酶活性.

Objective : To explore the relationship between polymorphism cytochrome P 4502 D 6 ( CYP 2 D 6 ) gene and schizophrenia in Chinese.

目的: 探测精神分裂症与细胞色素P4502D6基因多态性关系.

The recombinant CYP 3 A 4 plasmid was successfully cloned and effectively expressed in Rosetta ( DE 3 ) 2 pLysS.

成功地使CYP3A4基因在原核系统中高效表达.

Dex, Cyp and Ani markedly decreased TNF α mRNA level and TNF α immunoreactive material in rat liver.

Dex 、 Cyp或Ani均能显著降低大鼠肝脏TNFαmRNA水平和TNFα含量.

DEX is a typical inducer of CYP 3 A 4 , by a pregnane X receptor ( PXR ) mediated mechanism.

DEX是典型的CYP3A4诱导剂,其诱导机制由 PXR 介导.

One kind suppresses the person CYP 1 A enzyme vigor natural flavonoid.

一种抑制人CYP1A酶活力的天然黄酮类化合物.

To review PCR-based genotyping methods for genetic polymorphism of CYP 2 A 6 gene.

综述检测CYP2A6基因多态性的PCR技术的基因型方法.

Conclusions Our results indicate that CYP 2 D 6 C 188 T polymorphism associated with treatment-resistant schizophrenia of Chinese.

结论本组样本中CYP2D6C188T基因多态性与难治性精神分裂症关联.

CYP 450 gene has several mutant alleles leading to genetic polymorphisms in humans.

细胞色素P450氧化酶的基因具有遗传多态性,在人类存在等位基因的突变体.

Only one sample showed 2 D 6 A heterozygous in CYP 2 D 6, the remains are all wild homozygous.

250例CYP2D6中仅1例为2D6A杂合子,其余都是野生型纯合子.

Objective Discuss the correlation between the CYP 19 genetic polymorphism and endometrial cancer ( EC ) .

目的探讨 CYP19 基因多态性与子宫内膜癌的关联性.

Cytochrome P 450 ( CYP 450 ) plays an important role in the cause and therapy of tumors.

细胞色素氧化酶 P450 在肿瘤的发病和治疗中起着不容忽视的作用.