Bisphosphonates with a imidazole ring have higher affinity for bone mineral, and zoledronate is just a good example which is extensively used clinically for the treatment of patients with tumour-induced, hypercalcaemia and osteolytic bone metastases.

  • 含咪唑环的双膦酸盐具有很高的亲骨性,典型的例证是广泛用于治疗肿瘤引起的高钙血症、骨转移和骨质疏松症等方面疾病的唑来膦酸。

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