Conclusion Ibuprofen polylactide microspheres can treat CVS effectively. Its possible mechanisms may relate to the inhibition of inflammation reaction.

METHODS: The drug concentration in plasma was assayed by HPLC method after administration of a single oral dose of 400 mg ibuprofen to each of 8 healthy male volunteers.

方法：8名健康男性志愿者单剂量随机交叉po400mg布洛芬后，采用HPLC测定血浆药物浓度。

Ibuprofen group of thirty-two patients received ibuprofen 300 mg, po, bid, for 4 wk.

布洛芬组32例，给予布洛芬300mg，po，bid，疗程4wk。

HPLC Determination of Arginine Ibuprofen Dispersible Tablets

HPLC法测定精氨酸布洛芬分散片含量

Ibuprofen showed a limited protection CAT against inactivation by fructose, G6P and glucose but not SOD.

而布洛芬有限地保护糖基化诱导CAT的失活，对SOD的失活无保护作用。

Objective To synthesize ibuprofen eugenol ester and study its hydrolysis kinetics.

目的合成布洛芬丁香酚酯并研究其在不同pH水溶液中及血浆、肝匀浆中的水解动力学。

Results: The solubility of ibuprofen in water was increased after the formation of the complex, and an ibuprofen solution ( 100 mg/ mL) was obtained.

结果：形成复合物后布洛芬在水中的溶解度明显增加，其溶液浓度可达100mg/mL，最稳定pH范围是6.0~7.0。

Determination of Fenbufen Tablets by HPLC Determination of Ibuprofen and Sodium Phenobarbital in Compound Ibuprofen for Suspension by HPLC

HPLC法测定复方布洛芬干混悬剂中布洛芬及苯巴比妥钠的含量

Objective To determine the contents and the related substances of ibuprofen eugenol ester in microemulsion.

目的测定布洛芬丁香酚酯（ibuprofen eugenol ester，IEE）微乳中布洛芬丁香酚酯及有关物质的含量。

Results: The release behavior of the tablets follows the Higuchi equation;

结果：布洛芬不溶性骨架缓释片的药物释放规律符合Higuchi方程；

The proposed method has been applied for the analysis of compound ibuprofen tablets, and the analytical results are in good agreement with those obtained by HPLC method.

应用毛细管区带电泳法测定复方布洛芬片剂的含量，所得结果与HPLC法一致。

HPLC for the simultaneous determination of Ibuprofen and Pseudoephedrine hydrochloride in Ibuprofen and Pseudoephedrine dispersible tablets

HPLC法同时测定布洛伪麻分散片中布洛芬盐酸伪麻黄碱的含量

Objective To develop a rapid and specific HPLC-UV method for the determination of dexibuprofen in Beagle dog plasma, and use it to investigate the pharmacokinetics of dexibuprofen in Beagle dog plasma.

目的建立一种快速、专属的HPLC UV法用于测定比格犬血浆中右旋布洛芬的浓度，应用本法对右旋布洛芬缓释胶囊在比格犬体内的药物动力学行为进行研究。

Determination of Ibuprofen Guaiacol Ester and Its Related Substances by HPLC

布洛芬愈创木酚酯及有关物质的HPLC测定

Objective To elucidate the anti-inflammation mechanism of ibuprofen tetramethylpyrazine ester ( ITE).

目的探讨布洛芬川芎嗪酯（ITE）的抗炎机制。

NMR Studies of Chiral Discrimination of Ibuprofen Enantiomers in β-Cyclodextrin Inclusion Complexes

NMR研究β-环糊精对布洛芬的手性识别

Among the five chosen substrate, asymmetric hydrolysis of methyl ester or isopropyl ester formed S (+)-ibuprofen of 97% ee.

在试验的五种布洛芬消旋酯中，水解甲酯和异丙酯生成s（+）-布洛芬ee可达97%，乙酯为93%以上；

Moreover, a drug controlled-release system of mesoporous silica/ ibuprofen was synthesized under one step method with the ibuprofen containing nonionic surfactant as the template.

此外，以该药物端基非离子表面活性剂胶束为模板通过一步法合成了介孔SiO2－布洛芬药物释放体系。

While at the same DS level, the releasing rate increased with the increase of drug loading, decreased with the increase of compression stress.

同一取代度的HC对布洛芬的释放量随着载药量的增加而增加，随着成片压力的增加而下降。

Although the S (+)-enantiomer of ibuprofen is the eutomer with respect to inhibition of prostaglandin formation, the marketed products containing ibuprofen are almost all supplied as the racemate.

虽然许多体内外试验结果都表明，S（+）-布洛芬作为优对映体在抑制前列腺素生成上优于R（-）-布洛芬，然而，市售的产品中仍多数为消旋体形式。

This paper describes the syntheses and structural characterization of two amine salts of ibupro ˉ fenusing elemental analyses, IR and X_ray powder diffrac ˉ tion techniques.

合成了两个布洛芬有机胺盐，并用元素分析、红外和X射线粉末衍射对其结构进行了表征，首次报道了布洛芬乙胺盐的晶体结构。