The primary goal of the strategy is to selectively increase tumor cell exposure to cytotoxic drug metabolites generated locally by a prodrug-activating P450 enzyme, which expresses highly in tumor cells after being transduced.

OBJECTIVE: To investigate the effect of bayberry polyphenol ( BPP) on thrombopenia induced by cytotoxic drug and radiation in mice and rats.

目的：研究杨梅多酚对大、小白鼠在化学和辐射损伤中血小板减少的影响。

Objective: To reveal the synergistic antiangiogenic effects and mechanisms of novel recombinant human endostatin ( Endostar) combined with cytotoxic drug cisplatin.

目的：揭示新型重组人内皮抑素（Endostar，恩度）与细胞毒药物顺铂联合使用的抗血管形成作用，探讨联合用药方式产生协同作用的分子机制。

Objective: Chemical medicines for traditional cancer therapy are mostly Cytotoxic drug, which have defect of severe side effect, low selectivity and easy to cause drug-resistance.

目的：传统治疗肿瘤的化疗药物以细胞毒类药物为主，其毒副作用大、选择性低和易产生抗药性。

Methods: The antitumor effect of the therapeutic lipopeptide vaccine against cervical cancer by interferon-γ at the different concentration was investigated by cytotoxic test. The expression of HLA-A2 and CD54 on the tumor cell was detected by flow cytometry.

方法：采用细胞毒性试验观察不同剂量γ干扰素对宫颈癌治疗性脂肽疫苗的抗肿瘤作用的影响，采用流式细胞术检测宫颈癌细胞HLA-A2分子和CD54的表达。

In cytotoxic test by MTT method, there are 2,4,12 samples ′ inhibition rate to KB, Raji and Hep G2 respectively higher than 50% in 25 μ g/ mL.

在细胞毒实验中，分别有2个、4个和12个样品在浓度为25μg/mL时，对KB细胞、Raji细胞和Hep G2细胞的抑制率高于50%；

Safety evaluation of AMX-LH-NEThe safety of AMX-LH-NE was evaluated in vivo and in vitro by acute toxicity test, skin irritation test and cytotoxic test of mammary epithelial cells.

AMX-LH-NE的安全性评价通过急性毒性试验、皮肤刺激性试验和乳腺上皮细胞毒性试验，对AMX-LH-NE进行体内外安全性评价。

Method: The vacuolated effect and its relationship to VacA of H.pylori clinical isolates were investigated by the method of cytotoxic test 、 SDS-PAGE and scan.

方法：用细胞毒试验、SDS-PAGE结合薄层扫描研究H.pylori临床分离株空泡毒作用及其与VacA的关系。

Methods All the 747 patients with un-definition rheumatic diseases were detected HLA-B_ 27 by standard NIH micro-lymphocyte cytotoxic test.

方法采用标准NIH微量淋巴细胞毒实验方法对747例临床诊断不确定风湿性疾病患者做HLA-B27抗原检测。

Methods First, HA-contain bioceramic toxic tests including generalized toxic test, skin stimulation test, hemolytic test, Ames test and cytotoxic test were carried out.

方法首先将含羟基磷灰石生物陶瓷进行毒性试验，包括全身毒性试验、皮肤刺激试验、溶血试验、Ames试验及细胞毒性试验。

Method: The antiviral effects of this drug were observed by cytotoxic test on Hep-2 cells and direct antiviral test in vitro.

方法：采用细胞毒性试验，体外直接抗病毒试验观察本品的抗病毒作用。

Studies on Characteristics of Macrophage-derived Cytotoxic Factor

巨噬细胞细胞毒因子性质的研究

Study of cytotoxic factor and IL-2 induced by anti-tumor i-RNA

关于抗瘤免疫RNA诱生IL-2，细胞毒因子活性的研究

Study on seral cytotoxic factor activities of patients with viral infection of the upper respiratory tract

上呼吸道病毒感染患者血清细胞毒因子活性的研究

Study of cytotoxic factor induced by anti-tumor i-RNA

抗肿瘤免疫核糖核酸诱生细胞毒因子的研究

Effect of tumor cell component on the inducing macrophage cytotoxic factor

瘤细胞成分在诱生巨噬细胞分泌细胞毒因子中的作用

The Role of Cytotoxic Factor in Glomerulopathy

细胞毒因子在肾小球疾病中的作用

Cytotoxic factor in the spleen of mice infected with epidemic hemorrhagic fever virus

流行性出血热病毒感染小鼠脾脏中的细胞毒因子

Objective To study the mechanism and effect of tyrosine analogues on the content of uterine cytosol estradiol receptor ( ER) in preimplantation rats.

目的研究酪氨酸类似物对早孕大鼠子宫胞浆雌二醇受体含量的影响及其机制。

The Effect of Tyrosine Hydrazide on the Content of the Cytosol Estradiol Receptor of the Uterus in Preimplantation Rat

酪氨酸肼对着床前大鼠子宫胞浆雌二醇受体含量的影响

Significance of Both Nuclear and Cytosol Androgen Receptor ( AR) in Assessment of AR Status in Prostate Carcinoma and Hepatocellular Carcinoma

胞核雄激素受体测定对评价前列腺癌、肝癌受体状态的意义