The Study of Mechanism of Endogenous Toxic Bile Formation and Its Role in Bile Duct Injury after Liver Transplantation

The lumen of the bile canaliculus and the space of Disse were occluded by many microvilli extended by hepatocytes.

胆小管腔和窦周隙内浸润许多由肝细胞发出的微绒毛结构。

When the bile canaliculus developed to the last stage of the fetus, the tight junction closing the lumen developed into a perfect condition.

胆小管发育至胚胎晚期，封闭其管腔的紧密连接发育完善。

That of the PVD lobe ruined significantly and became worse by the time after operation. The number of hyperplasia bile canaliculus increased.

去门脉肝叶肝小叶结构破坏随术后时间的延长愈加明显，但增生的胆小管教目增多。

In an early embryo, a bile canaliculus has been found. A bile duct is evolved from original hepatic cell.

胆小管在胚胎早期已经形成，胆管由肝母细胞演化而来；

A bile canaliculus existed among 2 to 3 hepatocytes.

2～3个相邻的肝细胞间形成毛细胆管；

Freeze Fracture Etching Study of Tight Junctions in Bile Canaliculus

毛胆管紧密连接的冷冻蚀刻研究

GC analysis of common bile acids by capillary column

多种胆汁酸的毛细管柱气相色谱分析

3, To find out the effects of PBM on the bile using capillary reversed-phase liquid chromatography ( cRPLC).

3，通过毛细管柱反相液相色谱（cRPLC），观察PBM胆汁中胰酶的概貌；

Results: Among 9 postoperative ERCP, there were found: choledocholith residual 2, papillary stenosis 3, papillary edema 1, bile capillary fistula 1 and normal 2. All of these condition was cured by endoscopic therapy.

结果：术后9例ERCP中2例胆总管有残余结石，3例乳头狭窄，乳头水肿及毛细胆管瘘各1例，2例正常。对仍有病变患者均经内镜治疗而愈。

Ultra structure study showed that the BDD liver cells have plenty of mitochondrions, rough endoplasmic reticula ( RER) and free ribosomes. Its bile capillary cavity was narrow and the microvillus destroyed obviously.

透射电镜超微结构观察：去胆管肝叶肝细胞富含线粒体、粗面内质网和游离核糖体：毛细胆管腔缩小，其内微绒毛破坏明显。

The PVD liver cells revealed a decreased RER, plenty of smooth endoplasmic reticula. Its bile capillary structure showed relatively normal.

去门脉肝叶肝细胞胞浆中粗面内质网减少，滑面内质网增多，其毛细胆管结构显示正常。

Result: There were many pigment granules with monolayer adventitial coat in hepatocyte and around bile capillary.

观察结果：电镜下可见到肝细胞内及毛细胆管周围有大量的外有单层膜包绕的色素颗粒，颗粒大小不均匀；

The bile capillary dilated with decrease of microvilli and thickening of the wall.

毛细胆管扩张，腔内微绒毛减少，管壁增厚；

Applied anatomy on surgical access of hepatic bile ducts

肝胆管外科入路的应用解剖

Effect of the shame-rage on hepatic bile in cats

猫假怒反应对肝胆汁流量和血浆肾素活性的影响

Surgical treatment of primary hepatocellular carcinoma invading into the hepatic bile duct

原发性肝细胞癌侵入肝胆管的外科治疗

The treatment on syndrome of hepatic bile stagnation by TCM

中医药治疗肝内胆汁郁滞症

Effect of electrical vagal stimulation on rabbit hepatic bile flow

电刺激兔迷走神经对胆汁分泌的效应

223 specimens of hepatic bile and 39 specimens of gallbladder bile, including the acute, chronic, cholestatic, non-cholestatic cholecystitis and cholelithiasis, are collected.

采集肝胆汁（T管肝胆汁）5l例223份，胆囊胆汁39例标本，包括急性、慢性、梗阻和非梗阻性的胆囊炎和胆石症胆汁。

Conclusions: Shot term intravenous fat emulsion may affect hepatic bile lipid composition, but didnt increase lithogenicity of hepatic bile in human.

结论：短期输注脂肪乳剂可引起肝胆汁中脂质成分的改变，但并不增加肝胆汁的成石性。