lactacystin

Applying Lactacystin, a selective proteasome inhibitor, to set up the rat model of Parkinson's disease with Lewy body

应用蛋白酶体抑制剂Lactacystin建立有Lewy体的帕金森病大鼠模型

Effects of Lactacystin on the Expressions of Gene and Protein of Tyrosine Hydroxylase

Lactacystin对酪氨酸羟化酶基因和蛋白表达的影响

Experimental study of Parkinson ′ s disease rats induced by lactacystin

乳胞素诱导大鼠致帕金森病的实验研究

Synergistic Toxic Effect of Paraquat and Lactacystin on Substantia Nigra

百草枯与lactacystin对黑质细胞协同毒性作用

Conclusion: There is synergistic toxic effect between lactacystin and paraquat and the chronic exposure to paraquat can increase the risk for PD of rats with lightly impaired proteasome.

结论：lactacystin与PQ之间存在协同作用，长期小剂量PQ的暴露能显著增加蛋白酶体功能轻微损害的大鼠患PD的风险。

Aim : To study the effect of lactacystin on dopamine ltransporter ( DAT ) and vesicular monoamine transporter ( VMAT 2 ) protein expressions in rats striatum.

目的: 探讨蛋白酶体抑制剂lactacystin对大鼠纹状体多巴胺转运体 ( DAT ) 和囊泡单胺转运体2 ( VMAT2 ) 蛋白表达的影响.

PD rats that expressed Lewy body and presented lateral rotation were made by injecting 8 μ g lactacystin into one side of substantia nigra compact part of rat with stereotaxic technique.

在大鼠单侧黑质致密部（SNc）立体定向注射蛋白酶体抑制剂lactacystin8μg，建立表达Lewy小体并向偏侧旋转的PD大鼠。

Conclusion The rat model of Parkinson's disease with Lewy body is set up by using Lactacystin which can block the α-synuclein degradation.

结论利用蛋白酶体抑制剂Lactacystin阻碍α-synuclein的降解可以建立有Lewy体的PD大鼠模型。