the important affair of a final settlement in life -- marriage;the main affair of one's life;Marriage is a solemn decision.;a great [an important] event in one's life ;

Romance is the big event of a lifetime , far more important than gambling.
人家终身大事, 比赌钱要紧得多呢.
来源:汉英文学 - 围城This is a great event in his life and shouldn't be regarded as a trifling matter.
这可是他的终身大事,不可儿戏.
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