azoles

Azoles are the largest class of antifungal agents in clinical use. 1,2,3-Triazole moieties are attractive connecting units, as they are stable to metabolic degradation and capable of hydrogen bonding, which can be favorable in binding of biomolecular targets and solubility.

唑类是临床上应用最广泛的抗菌药物。1,2,3-三氮唑由于其不容易被生物降解和容易形成氢键增加了其与生物大分子的结合能力，被作为一个极具吸引力的连接单元广泛应用。

Studies on FKI-0076A, B, C& synergists of azoles antifungal antibiotics from microorganisms

微生物来源的Azole类抗真菌活性增强剂&FKI-0076A、B和C的研究

There is no report about the mechanisms of C. glabrata to azoles antifungal agents in China.

国内尚未见光滑假丝酵母菌对唑类抗真菌药物耐药机制的报道。

We examined the utility of agar dilution to screen yeasts for reduced susceptibility to several newer antifungal drugs including echinocandins and azoles.

我们研究了琼脂稀释法筛选对多种新型抗真菌药物包括棘白菌素和唑类敏感性降低酵母菌的实用性。

CONCLUSIONS Hospital acquired infection of deep fungus and resistance had an increasing tendency, evident resistance had been found in some antifungal drugs, especially azoles. So it is the time to take some effective control means.

结论深部真菌医院感染及耐药性呈上升趋势，特别是唑类抗真菌药已呈明显耐药，采用有效的防治措施刻不容缓。

Azoles as Composite Corrosion Inhibitor for Anti tarnishing of Silver Antiques I. Process of the Inhibition Film Formation and Assessment of Its Anti tarnishing Abilities

防止银器文物变色的唑系复合缓蚀剂&I.缓蚀剂成膜处理工艺与防变色性能的评定

Topical azoles applied for seven days are recommended for treatment during pregnancy.

妊娠期感染可局部用吡咯剂,共用七天.

There are two different interaction models between weakly basic azoles derivatives and thrombin.

弱碱性唑类凝血酶抑制剂与凝血酶的作用模式有两种。

These azoles present a broader antifungal spectrum and a more effective antifungal activity.

这些药物扩大了现有唑类药物的抗菌谱,提供了更好的抗真菌活性.

The corrosion control methods and corrosion inhibitors ( nitrites, orthophosphates, polyphosphates, polyol esters, phosphonates, zinc salts, silicates, molybdates, borates and aromatic azoles) in recirculating cooling water systems are discussed and emphasized.

重点讨论了金属腐蚀控制的方法以及金属腐蚀控制用的缓蚀剂&亚硝酸盐、正磷酸盐、聚磷酸盐、磷酸酯、有机膦酸、锌盐、硅酸盐、钼酸盐、硼砂和芳香唑类。

We added echinocandins and azoles to CHROMagar Candida medium prior to its solidification.

在显色琼脂固化之前，向显色琼脂念珠菌培基中加入棘白菌素和唑类。

Except terbinafine, Candida albicans strains were resistant to Azoles at different degrees, the non-Candida albicans resistence rates to Azole drugs were higher than Candida albicans.

除特比奈芬外，白假丝酵母菌和非白假丝酵母菌对唑类药物有不同程度的耐药，且非白假丝酵母菌的耐药率较高，二者差别有统计学意义。

Above results showed the combination of RAB and azoles could synergistically inhibit the biofilm formation through preventing the hyphae formation.

以上结果显示RAB可以与唑类药物联用，通过抑制菌丝的形成，协同抑制成熟被膜的形成，并表现出一定的杀菌效果。

The drug-resistant rate of yeast-like fungus to azoles increased by 9.6%~ 16.8% during the past four years.

4年间临床酵母样真菌对唑类药物的耐药率增加了9.6%~16.8%。

Research Progress of Azoles Pesticide

唑类农药研究进展

Conclusions: These results indicated that the resistance and cross-resistance to azoles could be induced in C.albicans, which are dependent on drug concentration and unstable.

结论：唑类药物能诱导耐药白念珠菌的产生，但与诱导药物的浓度有关，且为不稳定耐药。

The primary study of the induction of resistance to azoles in Candida albicans in vitro

唑类药物体外诱导白念珠菌耐药的初步研究