bone-deep

There were lots of bone-deep historical and cultural reasons.

中国戏剧的失语，有着深刻的历史、文化原因。

He'd felt like he'd run up and down the stairs a few times, but even that was an improvement over the bone-deep weakness he'd been battling all year.

这让他觉得自己像是楼上楼下奔跑了好几趟似的那样累，但是这也这一年来对抗深入骨髓的虚弱的进步。

Regarding earthquake, especially about disastrous earthquake, there is bone-deep remain in my mind.

地震，尤其是这种巨震，给我的印象太深刻了，刻骨难忘！

But he did not change to be a little bit friendly to me, on the contrary, often jeered at me with a bone-deep envies and hates to show he was more superior to me in many aspects after all.

可是，他并没有从此对我态度好一点，相反，还时时刻刻带着一种刻骨的忌恨嘲讽我，以示他毕竟有个什么地方比我优越。