hypercalcaemia

PURPOSE To evaluate the efficacy, convenient dosage and side effect of pamidronate for metastatic bone pain and hypercalcaemia of malignancy.

目的观察国产帕米膦酸二钠（APD）对恶性肿瘤溶骨转移疼痛的止痛作用，对恶性肿瘤并发高钙血症的治疗作用，合适的临床剂量及不良反应。

Multiple myeloma is a malignant plasma cell disorder. And it is characterized by heterogeneous anemia, bone disease, renal impairment, hypercalcaemia and infections due to patchy accumulation of malignant plasma cells within the marrow microenvironment.

多发性骨髓瘤（MM）是一种浆细胞恶性增殖性疾病，其特点是恶性浆细胞在骨髓微环境中不规则积聚引起的不同程度贫血、骨破坏、肾功能不全、高钙血症和感染。

The effective rate of moving ability improvement was 84.4%. After treatment, nine patients with hypercalcaemia whose serum calcium reduced to normal in 77.78%.

活动能力改善有效率为84.4%，9例血钙增高患者经治疗后血钙复常率为77.78%。

Hypercalcaemia and bone metastases of malignancy are frequently diseases in advanced cancer patients, it threatens patients' life and brings the patients with great pain.

高钙血症和恶性肿瘤骨转移是晚期肿瘤患者的常见疾病，危及患者的生命并给患者带来巨大的痛苦。

An Animal Model of Cancer Related Hypercalcaemia Induced by Walker_ ( 256) Carcinoma in Rats Carcinosarcoma

Walker（256）癌肉瘤引发大鼠高血钙模型

Bisphosphonates with a imidazole ring have higher affinity for bone mineral, and zoledronate is just a good example which is extensively used clinically for the treatment of patients with tumour-induced, hypercalcaemia and osteolytic bone metastases.

含咪唑环的双膦酸盐具有很高的亲骨性，典型的例证是广泛用于治疗肿瘤引起的高钙血症、骨转移和骨质疏松症等方面疾病的唑来膦酸。