ioversol

Objective: To synthesize ioversol, a non-ionic x-ray contrast agent.

目的：合成非离子型X线造影剂碘佛醇。

Results The viability of rat glomerular endothelial cells was inhibited by ioversol in a concentration and time dependent manner.

结果非离子型低渗造影剂碘佛醇能显著降低大鼠肾小球内皮细胞存活率，并呈剂量和时间依赖性。

Synthesis of ioversol, a non-ionic x-ray contrast agent

非离子型X线造影剂碘佛醇的合成

Further investigations showed that the viability of rat glomerular endothelial cells was inhibited by Ioversol in a dose-and time-dependent manner.

碘佛醇可以导致肾小球内皮细胞存活率下降，并呈明显的剂量和时间依赖性。

Methods Rat glomerular endothelial cells were exposed to ioversol with different concentrations for different time.

方法不同浓度和时间的碘佛醇（Ioversol）作用于体外培养的大鼠肾小球内皮细胞，用噻唑蓝（MTT）法检测细胞存活率。

Results After being incubated with Diatrizoate or Ioversol for 1 h, the renal artery endothelium did not show significant changes in the release of NO, but the release of ET-1 increased in a dose-dependent manner.

结果肾动脉血管环在含泛影葡胺和碘佛醇的培养液中孵育1h后，NO分泌无明显变化，而ET-1分泌增加，且呈剂量依赖性。

Objective: To establish a method for quantification of residual methanol, n-butanol and 2-methoxyethanol in drug substance ioversol.

目的：建立碘佛醇原料药中甲醇、正丁醇和2-甲氧基乙醇残留量的测定方法。