The biosynthesis of spiramycin ( SPM) by streptomyces spiramyceticus sp.799 was regulated by carbon and nitrogen catabolite repression as well as end products feedback repression.

  • 本文采用强烈因子处理的诱变方法,配合理性化筛选技术,有意识地消除一些分解代谢物的阻遏和产物对螺旋霉素生物合成的反馈抑制。

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