A Convenient Method for Calculating the Median Lethal Dose in Toxicity Testing

Computer program calculating median lethal dose of drugs

药物半数致死量的计算程序

Median lethal time, mean lifespan and mean maximum lifespan of drosophila fed with different concentration of ponceau 4R were lower than those in control groups dominantly ( P < 0.05 or P < 0.01) in survival experiment, and a dose-response relationship was shown.

生存试验中各浓度组雌雄果蝇的半数死亡时间、平均寿命及平均最高寿命均较对照组缩短（P<0.05或P<0.01），且存在剂量-反应关系。

The median lethal time ( LT50) of the GV was shortened with the increase of the virus concentration and the decrease of the larval instar, during which the GV was fed.

幼虫饲毒后，致死中时（LT（50））随病毒浓度提高而缩短；随饲毒时虫龄的增大而延长。

The median lethal time ( LT_ ( 50)) of P_ ( f) NPV to the larvae was shortened with the increase of the viral concentration.

各测试浓度下致死中时间（LT（50）为3.43-5.14天，随病毒浓度提高而缩短。

The most virulent strain was screened out after evaluated by the indices of mortality, infection rate and the median lethal time ( LT50).

以桃蚜的校正死亡率、感染率及致死中时（LT（50））为指标综合评价不同菌株毒力。

Conclusion Nano-hydroxyapatite has no accumulative toxicity to rabbits, it is suggested that it is safe when the hydroxyapatite-sol was applied intravenously as a drug carrier in small dosage more less than the medium lethal dose, even as a kind of anticancer drug.

结论纳米HAP在家兔无明显蓄积毒性，提示当用量远远小于最小致死剂量时，纳米HAP可作为药物载体，甚至在将来可能作为一种新型的抗癌药物，经静脉安全应用。

The oral acute toxicity test showed LD50 ( medium lethal dose)> 5.5 g/ Kg. Such result demonstrates that the synthesized product is nontoxic according to the classification of acute toxicity standard.

通过对合成的产物进行急性经口毒性试验，发现其经口半数致死量（LD50，medium lethal dose）大于5.5g/Kg，按照急性毒性分级标准确定该依布硒林衍生物属实际无毒级。

The reasonable time of ultraviolet radiation treatment to urediospores of Chinese wheat yellow rust race 29 ( CY29-3) is the time of 90% relative percentage of lethality of urediospores. The 88.97% relative percentage of lethality of urediospore was gotten after 8 minutes ultraviolet radiation treatment.

以夏孢子相对致死率90%左右作为紫外线处理最适时间，发现8min为小麦条锈菌条中29号单孢菌系（CY29-3）最适处理时间，其夏孢子相对致死率达88.97%。

The ultra-structural changes of Monopterus albus liver cells were observed with transmission electron microscopy after sublethal exposure to Cu2+ and nonionic surfactant AE ( linear alkylethoxylate).

利用透射电镜研究了亚致死浓度的Cu2+或表面活性剂AE（脂肪醇聚氧乙烯醚）对黄鳝肝细胞结构的损伤作用。

CONCLUSION: With the increase of HIFU irritation time, the survival rate of tumor cells presents the linear decrease tendency. And 1 000 W/ cm2 × 30 seconds is the minimum dose of bringing cells into complete dead and breaking them into debris.

结论：当高强度聚焦超声声强固定为1000W/cm2时，细胞存活率随高强度聚焦超声辐照时间延长呈直线下降，1000W/cm2×30s是能灭活肿瘤细胞且使之完全破碎的剂量。

Conclusion: The minimum dose of active DNA to induce SLE-like syndrome was 10^ tg, and it predominantly evoked the humoral response.

结论：10腭活性DNA即可诱导小鼠SLE样综合征，主要诱导自身体液免疫应答。

The elaboratively-designed treatment plan is capable of having the tumor receive higher dose level while the normal tissues and organs receive minimum dose level.

结果表明，精心设计的治疗计划能使肿瘤区域接受到高的治疗剂量，而周围正常组织和器官接受的剂量最少。

It was the better way to use the mid dose CF combined with the minimum dose 5 Fu in the treatment of advanced colonic cancer.

中剂量醛氢叶酸与小剂量氟脲嘧啶是治疗晚期肠癌的较好组合。

The minimum dose of N. gonorrhoeae which can be detected by ELISA was 1 × 10 4 bacteria per ml.

淋球菌的最小检测量为1×104个／ml。

Minimum dose of protection of recombinant pseudorabies virus ( rPRV-GP5) against pseudorabies in sheep

重组伪狂犬病毒（rPRV-GP5）对伪狂犬病最小免疫剂量的测定

Objective To probe the minimum dose for trial diagnostic radiation of suspected intracranial germinoma.

目的探讨拟诊颅内生殖细胞瘤试验性放疗的最低剂量。

The results showed that the minimal lethal dose of Norfloxacin to embryos is 320mg/ kg embryo weight, and the lethal dose 50% ( LD60) for 3-day-old chicks 4 985+ 753.18 tag/ kg body weight.

结果表明，氟哌酸对鸡胚的最小致死剂量为320mg/kg胚重；对3日龄雏鸡的LD（50）为4985±753.18mg/kg体重。

Methods: To carry out external bacteriostasis experiment first by the method of drilling hole, then To definite minimal lethal dose by preliminary test, finally to do internal bacteriostasis experiment with mice.

方法：先采用打孔法进行体外抑菌试验，然后通过预试验找到最小致死浓度，最后用小白鼠进行体内抑菌试验。

Protection mechanism of mice transferred by AAV 2-BPI_ ( 700)-Fc γ 1_ ( 700) recombinant virus to minimal lethal dose E.coli infection

AAV2-BPI（700）-Fcγ1（700）重组病毒导入小鼠对致死量大肠埃希菌感染的保护作用机制

Objective To observe the resistance of mice that were transfected with BPI_700-Fc γ 1_700 chimera gene to minimal lethal dose ( MLD) of E.

目的通过观测BPI700-Fcγ1700嵌合基因导入小鼠对最小致死量E。