PMX caused DNA damages in murine embryonic stem cells, oxidative stress injuries of mice and apoptosis of embryonic stem cells, leading to abnormal closure of neural tube and ultimately NTDs.

  • 体外实验中,PMX可以损伤小鼠胚胎干细胞DNA,造成小鼠氧化应激损伤,使胚胎干细胞发生凋亡,最终使神经管不能发生正常闭合,而导致神经管畸形的发生。

  • 互联网摘选 2025-01-20 17:38:59

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