However obese women with PCOS often report extreme difficulty in loosing weight and maintaining weight loss.

When asthma is most severe, the person may have extreme difficulty breathing.

哮喘严重的情况下，人会感到呼吸非常困难。

The extreme difficulty in tracing the manufacturing and distribution channels of SFFC medicines makes their circulation on markets difficult to stop.

由于在追查制造假冒药品及其分销渠道上困难重重，因而难以阻止假冒药品在市场上的流通。

Past structural studies of methylation were hindered by the extreme difficulty of constructing homogeneous samples of histones bearing methyl groups attached to specific lysine residues.

过去甲基化的结构研究被阻碍的原因是因为很难制备组蛋白特定部位赖氨酸甲基化的均一样品。

Translation is difficult, but not more difficult than the poetry translation; as a part of poetry translation, the translation of classical Chinese poetry is particularly of extreme difficulty.

翻译难，译诗更难，翻译中国古典诗歌更是难上加难。

PoF system ( Power over Fiber System) is an electrical power transmission over fiber system for safe and reliable power supply purpose in high voltage and strong electromagnetic interference and other extreme difficulty environments.

激光供能系统是应用于高电压、强电磁干扰等极端恶劣环境下的以安全可靠供电为最终目的的光电能量传输系统。

Yet these hopes underestimated the sheer staying power – indeed the legitimacy – of the state and its institutions, and the extreme difficulty of creating new ones from scratch.

但是，这些预期低估了国家及国家机构的巨大耐久力（其实就是其合法性），以及从无到有创建新机构的极端困难性。

But when it comes to volcanoes, the extreme difficulty lies in putting the right amount of fluid in the right place so as not to inadvertently generate the very collapse that is meant to be avoided.

但当场景搬到了火山岛，最困难的部份，便是如何拿捏适量的水注入适当的位置，免得当初是为了避免崩坍，最后却不慎导致崩坍。

It was with extreme difficulty that Nipper, the black-eyed, who looked on steadfastly, contained herself at this crisis, and until the subsequent departure of Mrs Chick.

在奇克夫人随后离开之前，一直在密切注视着黑眼睛的尼珀，在这关键性的时刻，她很困难地克制着自己。

The Central TV Transmission Tower in Beijing with a height of 405m is mainly a prestressed concrete structure designed according to earthquake intensity 9.It has the peculiarities of complexity in structure and extreme difficulty in construction with urgent construction time limit and high construction quality demanded.

北京中央电视发射塔的设计塔高为405m，该塔采用预应力混凝土结构，按9度地震设防，结构复杂，工期紧迫，质量要求高，施工难度较大。

Less severe symptoms of yew berry poisoning include diarrhea, headache, dizziness, muscle weakness, stomach pain, vomiting, trembling and dilated pupils, while the scarier symptoms include extreme difficulty breathing, coma, convulsions, irregular heartbeat and, of course, death.

轻微中毒的症状包括痢疾、头痛、头晕、肌无力、胃痛、轻微颤抖和瞳孔扩散。更可怕的症状包括严重的呼吸困难、昏迷、抽搐、不规则心跳和死亡。

If anything, this experiment demonstrates the extreme difficulty of reaching a consensus on the ethics of driverless cars.

如果说有任何收获的话，那就是这个实验证明，要在无人驾驶汽车的道德上达成共识是极其困难的。

We are all under the illusion that the country is doing well economically, but in fact it is in serious difficulty.

我们都误以为这个国家经济状况良好，但是实际上它正处于严重的困难之中。

Everyone agrees that liquid pollution namely a serious difficulty today.

大家一致认为水污染已是当今的严重问题。

These organs appear at first to offer another and far more serious difficulty.

起初看来，这些器官好象还引起另外一个更为严重的难点。

Were it not for their assistance, we would be in serious difficulty.

要是没有他们的帮助，我们会陷入困境。

It has its own peculiar law of development characteristic features, but at present it has fallen into serious difficulty.

它有着特殊的发展规律与特点，但目前也面临着特殊的困境。

The prevention and cure of temperature cracks in large concrete pier cap is a serious difficulty in quality controlling of construction.

文章以某构筑物承台大体积混凝土施工为例，就大体积承台混凝土施工的施工工艺及温度控制进行了论述。

In fact, the theory that the universe has existed forever is in serious difficulty with the Second Law of Thermodynamics.

事实上，宇宙永恒存在的理论与热力学第二定理有严重不符

The morbidly obese man was was found amid a pile of the refuse with serious difficulty breathing.

这名胖子在一堆垃圾中被找到，当时他呼吸困难。

Taking particular account of the serious difficulty of the least-developed countries in view of their special economic situation and their development, trade and financial needs;

特别考虑到最不发达国家由于特殊的经济状况及其在发展、贸易和财政方面的需要而存在的严重困难；