Clinical research of treatment with tumor specific cytotoxic T lymphocyte in patients with carcinoma

The Detection of Cytotoxic T Lymphocyte about its Activity and its Application

细胞毒性T淋巴细胞活性的检测及应用

Result: B7-1 gene modified tumor cells can stimulate splenocyte growth apparently. Vaccination with allicin and MBT-2 B 7 · 1 generated the strongest cytotoxic lymphocyte responses to parental MBT-2 tumor cells.

结果：B7.1转基因肿瘤疫苗能有效刺激淋巴细胞增殖。当B7·1转基因肿瘤疫苗与大蒜素联合应用时，具有最大的抗肿瘤效果。

Objective To investigate the role of soluble form of cytotoxic lymphocyte associated antigen-4 CTLA-4 ( sCTLA-4) in the pathogenesis of atopic asthma.

目的探讨血清可溶性细胞毒T淋巴细胞相关抗原-4（sCTLA-4）在哮喘发病机制中的作用。

Objective To investigate the specific induction of cytotoxic lymphocyte ( CTL) by tumor derived heat shock protein 90 peptide complexes ( HSP90 PC).

目的探讨肿瘤组织来源的热休克蛋白90肽复合物（HSP90PC）诱导产生特异性细胞毒性T淋巴细胞（CTL）的作用。

Objective To study the biological characters of cytotoxic lymphocyte ( CTL) transduced with TNF-α gene.

目的：构建TNFα基因转染的CTL，并对其生物学特性进行研究。

The cytotoxic effect of antitumor drug on Hep-2 cell was achieved by inducing apoptosis.

对人喉癌Hep-2细胞的细胞毒作用主要是通过诱导凋亡实现的。

This study was designed to investigate anti tumor effects of differentiation inducing agent in combination with cytotoxic chemotherapeutic drug against glioma.

本研究旨在探讨诱导分化剂与细胞毒化疗药抗胶质瘤的联合效应。

There is comparability but no statistical significance in the basic clinical data in each group.3.Chemo-therapeutical schedule: the same schedule was adopted ( the third generation cytotoxic drug combined with Platinum), namely paclitaxel plus cisplatin. 4.

两组患者基本临床资料具有可比性，无统计学意义。（3）化疗方案：采用相同的化疗方案（第三代细胞毒药物联合铂类）即顺铂联合紫杉醇。

The primary goal of the strategy is to selectively increase tumor cell exposure to cytotoxic drug metabolites generated locally by a prodrug-activating P450 enzyme, which expresses highly in tumor cells after being transduced.

这种方法的首要目标就是选择性地使细胞色素P450在肿瘤细胞内超量表达。

OBJECTIVE: To investigate the effect of bayberry polyphenol ( BPP) on thrombopenia induced by cytotoxic drug and radiation in mice and rats.

目的：研究杨梅多酚对大、小白鼠在化学和辐射损伤中血小板减少的影响。

Objective: To reveal the synergistic antiangiogenic effects and mechanisms of novel recombinant human endostatin ( Endostar) combined with cytotoxic drug cisplatin.

目的：揭示新型重组人内皮抑素（Endostar，恩度）与细胞毒药物顺铂联合使用的抗血管形成作用，探讨联合用药方式产生协同作用的分子机制。

Objective: Chemical medicines for traditional cancer therapy are mostly Cytotoxic drug, which have defect of severe side effect, low selectivity and easy to cause drug-resistance.

目的：传统治疗肿瘤的化疗药物以细胞毒类药物为主，其毒副作用大、选择性低和易产生抗药性。

Methods: The antitumor effect of the therapeutic lipopeptide vaccine against cervical cancer by interferon-γ at the different concentration was investigated by cytotoxic test. The expression of HLA-A2 and CD54 on the tumor cell was detected by flow cytometry.

方法：采用细胞毒性试验观察不同剂量γ干扰素对宫颈癌治疗性脂肽疫苗的抗肿瘤作用的影响，采用流式细胞术检测宫颈癌细胞HLA-A2分子和CD54的表达。

In cytotoxic test by MTT method, there are 2,4,12 samples ′ inhibition rate to KB, Raji and Hep G2 respectively higher than 50% in 25 μ g/ mL.

在细胞毒实验中，分别有2个、4个和12个样品在浓度为25μg/mL时，对KB细胞、Raji细胞和Hep G2细胞的抑制率高于50%；

Safety evaluation of AMX-LH-NEThe safety of AMX-LH-NE was evaluated in vivo and in vitro by acute toxicity test, skin irritation test and cytotoxic test of mammary epithelial cells.

AMX-LH-NE的安全性评价通过急性毒性试验、皮肤刺激性试验和乳腺上皮细胞毒性试验，对AMX-LH-NE进行体内外安全性评价。

Method: The vacuolated effect and its relationship to VacA of H.pylori clinical isolates were investigated by the method of cytotoxic test 、 SDS-PAGE and scan.

方法：用细胞毒试验、SDS-PAGE结合薄层扫描研究H.pylori临床分离株空泡毒作用及其与VacA的关系。

Methods All the 747 patients with un-definition rheumatic diseases were detected HLA-B_ 27 by standard NIH micro-lymphocyte cytotoxic test.

方法采用标准NIH微量淋巴细胞毒实验方法对747例临床诊断不确定风湿性疾病患者做HLA-B27抗原检测。

Methods First, HA-contain bioceramic toxic tests including generalized toxic test, skin stimulation test, hemolytic test, Ames test and cytotoxic test were carried out.

方法首先将含羟基磷灰石生物陶瓷进行毒性试验，包括全身毒性试验、皮肤刺激试验、溶血试验、Ames试验及细胞毒性试验。

Method: The antiviral effects of this drug were observed by cytotoxic test on Hep-2 cells and direct antiviral test in vitro.

方法：采用细胞毒性试验，体外直接抗病毒试验观察本品的抗病毒作用。

Studies on Characteristics of Macrophage-derived Cytotoxic Factor

巨噬细胞细胞毒因子性质的研究